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Engineering Periodic shRNA for Enhanced Silencing Efficacy

RNA interference (RNAi) provides a versatile therapeutic approach via silencing of specific genes, particularly undruggable targets in cancer and other diseases. However, challenges in the delivery of small interfering RNA (siRNA) have hampered clinical translation. Polymeric or periodic short hairp...

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Bibliografiska uppgifter
I publikationen:Mol Ther
Huvudupphovsmän: Wu, Connie, Shopsowitz, Kevin E, Hammond, Paula T
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923333/
https://ncbi.nlm.nih.gov/pubmed/27053374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.69
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