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CD4 aptamer-RORγt shRNA Chimera Inhibits IL-17 Synthesis by Human CD4(+) T cells
Cell type specific delivery of RNAi to T cells has remained to be a challenge. Here we describe an aptamer mediated delivery of shRNA to CD4(+) T cells targeting RORγt to suppress Th17 cells. A cDNA encoding CD4 aptamer and RORγt shRNA was constructed and the chimeric CD4 aptamer-RORγt shRNA (CD4-As...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4216182/ https://ncbi.nlm.nih.gov/pubmed/25241192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.09.037 |
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