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MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches
The antitumor drug 5-fluoro-2’-deoxyuridine (FdUrd) also sensitizes tumor cells to ionizing radiation in vitro and in vivo. While radiosensitization with FdUrd requires dTTP depletion and S-phase arrest, the exact mechanism by which these events produce radiosensitization remains unknown. We hypothe...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2615187/ https://ncbi.nlm.nih.gov/pubmed/18535288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.043349 |
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