Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice

Genetic instability, which leads to an accumulation of various genetic abnormalities, has been considered an essential component of the human neoplasic transformation process. However, the molecular basis of genomic instability during tumorigenesis remains incompletely understood. Growing evidence i...

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Main Authors: Fu, Zheng, Regan, Kevin, Zhang, Lizhi, Muders, Michael H., Thibodeau, Stephen N., French, Amy, Wu, Yanhong, Kaufmann, Scott H., Lingle, Wilma L., Chen, Junjie, Tindall, Donald J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735912/
https://ncbi.nlm.nih.gov/pubmed/19690386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37405
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