Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here, we report that down-regulation of deoxyribonucleoside pools is another endog...

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Detaylı Bibliyografya
Asıl Yazarlar: Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Natarajan, Venkatesh, Zucker, Shoshanna N., Fink, Emily E., Im, Michael, Flanagan, Sheryl, Burhans, William C., Zeitouni, Nathalie C., Shewach, Donna S., Mathews, Christopher K., Nikiforov, Mikhail A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2013
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532713/
https://ncbi.nlm.nih.gov/pubmed/23245831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.09.011
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