Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here, we report that down-regulation of deoxyribonucleoside pools is another endog...

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Détails bibliographiques
Auteurs principaux: Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Natarajan, Venkatesh, Zucker, Shoshanna N., Fink, Emily E., Im, Michael, Flanagan, Sheryl, Burhans, William C., Zeitouni, Nathalie C., Shewach, Donna S., Mathews, Christopher K., Nikiforov, Mikhail A.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2013
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532713/
https://ncbi.nlm.nih.gov/pubmed/23245831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.09.011
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