Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human metastatic melanoma lines via lentivirus-based shRNAs approximately to the levels detected in normal melanocytes. C-MYC depletion did not significantly affect levels of E2F1 pr...

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Auteurs principaux: Mannava, Sudha, Grachtchouk, Vladimir, Wheeler, Linda J., Im, Michael, Zhuang, Dazhong, Slavina, Elena G., Mathews, Christopher K., Shewach, Donna S., Nikiforov, Mikhail A.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744895/
https://ncbi.nlm.nih.gov/pubmed/18677108
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