C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

Malignant melanomas often harbor activating mutations in BRAF (V600E) or, less frequently, in NRAS (Q61R). Intriguingly, the same mutations have been detected at higher incidences in benign nevi, which are largely composed of senescent melanocytes. Overexpression of BRAF(V600E) or NRAS(Q61R) in huma...

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Detalhes bibliográficos
Main Authors: Zhuang, D, Mannava, S, Grachtchouk, V, Tang, W-H, Patil, S, Wawrzyniak, JA, Berman, AE, Giordano, TJ, Prochownik, EV, Soengas, MS, Nikiforov, MA
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808965/
https://ncbi.nlm.nih.gov/pubmed/18679422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.258
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