Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

Chromosomal instability in early cancer stages is caused by stress on DNA replication. The molecular basis for replication perturbation in this context is currently unknown. We studied the replication dynamics in cells in which a regulator of S phase entry and cell proliferation, the Rb-E2F pathway,...

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Bibliografische gegevens
Hoofdauteurs: Bester, Assaf C., Roniger, Maayan, Oren, Yifat S., Im, Michael M., Sarni, Dan, Chaoat, Malka, Bensimon, Aaron, Zamir, Gideon, Shewach, Donna S., Kerem, Batsheva
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740329/
https://ncbi.nlm.nih.gov/pubmed/21529715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.044
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