Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

Chromosomal instability in early cancer stages is caused by stress on DNA replication. The molecular basis for replication perturbation in this context is currently unknown. We studied the replication dynamics in cells in which a regulator of S phase entry and cell proliferation, the Rb-E2F pathway,...

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Main Authors: Bester, Assaf C., Roniger, Maayan, Oren, Yifat S., Im, Michael M., Sarni, Dan, Chaoat, Malka, Bensimon, Aaron, Zamir, Gideon, Shewach, Donna S., Kerem, Batsheva
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740329/
https://ncbi.nlm.nih.gov/pubmed/21529715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.044
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