Metabolism in Human Cells of the d and l Enantiomers of the Carbocyclic Analog of 2′-Deoxyguanosine: Substrate Activity with Deoxycytidine Kinase, Mitochondrial Deoxyguanosine Kinase, and 5′-Nucleotidase

The carbocyclic analog of 2′-deoxyguanosine (CdG) has broad-spectrum antiviral activity. Because of recent observations with other nucleoside analogs that biological activity may be associated the l enantiomer rather than, as expected, with the d enantiomer, we have studied the metabolism of both en...

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Detalhes bibliográficos
Principais autores: Bennett, L. Lee, Allan, Paula W., Arnett, Gussie, Shealy, Y. Fulmer, Shewach, Donna S., Mason, William S., Fourel, Isabelle, Parker, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC105742/
https://ncbi.nlm.nih.gov/pubmed/9593124
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