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Metabolism in Human Cells of the d and l Enantiomers of the Carbocyclic Analog of 2′-Deoxyguanosine: Substrate Activity with Deoxycytidine Kinase, Mitochondrial Deoxyguanosine Kinase, and 5′-Nucleotidase

The carbocyclic analog of 2′-deoxyguanosine (CdG) has broad-spectrum antiviral activity. Because of recent observations with other nucleoside analogs that biological activity may be associated the l enantiomer rather than, as expected, with the d enantiomer, we have studied the metabolism of both en...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Bennett, L. Lee, Allan, Paula W., Arnett, Gussie, Shealy, Y. Fulmer, Shewach, Donna S., Mason, William S., Fourel, Isabelle, Parker, William B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105742/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9593124/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.5.1045
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