Antiapoptotic roles of ceramide-synthase-6-generated C(16)-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

Por Senkal, Can E., Ponnusamy, Suriyan, Bielawski, Jacek, Hannun, Yusuf A., Ogretmen, Besim
Publicado em 2010

Sphingolipids in Mitochondria

Por Hernández-Corbacho, María José, Salama, Mohamed F., Canals, Daniel, Senkal, Can E., Obeid, Lina M.
Publicado no Biochim Biophys Acta (2016)

Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells

Por Meyers-Needham, Marisa, Ponnusamy, Suriyan, Gencer, Salih, Jiang, Wenhui, Thomas, Raquela J, Senkal, Can E, Ogretmen, Besim
Publicado em 2012

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function

Por Sultan, Iyad, Senkal, Can E., Ponnusamy, Suriyan, Bielawski, Jacek, Szulc, Zdzislaw, Bielawska, Alicja, Hannun, Yusuf A., Ogretmen, Besim
Publicado em 2005

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

Por Ponnusamy, Suriyan, Meyers-Needham, Marisa, Senkal, Can E, Saddoughi, Sahar A, Sentelle, David, Selvam, Shanmugam Panneer, Salas, Arelis, Ogretmen, Besim
Publicado em 2010

Alteration of Ceramide Synthase 6/C(16)-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca(...

Por Senkal, Can E., Ponnusamy, Suriyan, Manevich, Yefim, Meyers-Needham, Marisa, Saddoughi, Sahar A., Mukhopadyay, Archana, Dent, Paul, Bielawski, Jacek, Ogretmen, Besim
Publicado em 2011

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner

Por El Osta, Mohamad, Liu, Mengling, Adada, Mohamad, Senkal, Can E., Idkowiak-Baldys, Jolanta, Obeid, Lina M., Clarke, Christopher J., Hannun, Yusuf A.
Publicado em 2014

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

Por Hernández-Corbacho, María José, Canals, Daniel, Adada, Mohamad M., Liu, Mengling, Senkal, Can E., Yi, Jae Kyo, Mao, Cungui, Luberto, Chiara, Hannun, Yusuf A., Obeid, Lina M.
Publicado no J Biol Chem (2015)

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

Por Mukhopadhyay, Archana, Saddoughi, Sahar A., Song, Pengfei, Sultan, Iyad, Ponnusamy, Suriyan, Senkal, Can E., Snook, Christopher F., Arnold, Hugh K., Sears, Rosalie C., Hannun, Yusuf A., Ogretmen, Besim
Publicado em 2009

Clinical Relevance of Ceramide Metabolism in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma (HNSCC): Attenuation of C(18)-ceramide in HNSCC Tumors Correlates with...

Por Karahatay, Serdar, Thomas, Kesha, Koybasi, Serap, Senkal, Can E., ElOjeimy, Saeed, Liu, Xiang, Bielawski, Jacek, Day, Terry A., Boyd Gillespie, M, Sinha, Debajyoti, Norris, James S., Hannun, Yusuf A., Ogretmen, Besim
Publicado em 2007

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

Por Patwardhan, Gauri A., Zhang, Qian-Jin, Yin, Dongmei, Gupta, Vineet, Bao, Jianxiong, Senkal, Can E., Ogretmen, Besim, Cabot, Myles C., Shah, Girish V., Sylvester, Paul W., Jazwinski, S. Michal, Liu, Yong-Yu
Publicado em 2009

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

Por Sentelle, R. David, Senkal, Can E., Jiang, Wenhui, Ponnusamy, Suriyan, Gencer, Salih, Selvam, Shanmugam Panneer, Ramshesh, Venkat K., Peterson, Yuri K., Lemasters, John J., Szulc, Zdzislaw M., Bielawski, Jacek, Ogretmen, Besim
Publicado em 2012

Results of a Phase II Trial of Gemcitabine plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C(18)-ceramide as a Novel Biomarker for Monitoring Response

Por Saddoughi, Sahar A., Garrett-Mayer, Elizabeth, Chaudhary, Uzair, O’Brien, Paul, Afrin, Larry, Day, Terry A., Gillespie, M. Boyd, Sharma, Anand, Wilhoit, Christina, Bostick, Robin, Senkal, Can E., Hannun, Yusuf A., Bielawski, Jacek, Simon, George, Shirai, Keisuke, Ogretmen, Besim
Publicado em 2011

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A

Por Salas, Arelis, Ponnusamy, Suriyan, Senkal, Can E., Meyers-Needham, Marisa, Selvam, Shanmugam Panneer, Saddoughi, Sahar A., Apohan, Elif, Sentelle, R. David, Smith, Charles, Gault, Christopher R., Obeid, Lina M., El-Shewy, Hesham M., Oaks, Joshua, Santhanam, Ramasamy, Marcucci, Guido, Baran, Yusuf, Mahajan, Sandeep, Fernandes, Daniel, Stuart, Robert, Perrotti, Danilo, Ogretmen, Besim
Publicado em 2011

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Por Saddoughi, Sahar A, Gencer, Salih, Peterson, Yuri K, Ward, Katherine E, Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M, Thomas, Raquela J, Selvam, Shanmugam P, Senkal, Can E, Garrett-Mayer, Elizabeth, De Palma, Ryan M, Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A, Stahelin, Robert V, Perrotti, Danilo, Ogretmen, Besim
Publicado em 2013