Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner

Protein kinase C (PKC) is a family of serine/threonine kinases implicated in a variety of physiological processes. We have shown previously that sustained activation of the classical PKCα and PKCβII induces their phospholipase D (PLD)-dependent internalization and translocation to a subset of the re...

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Autori principali: El Osta, Mohamad, Liu, Mengling, Adada, Mohamad, Senkal, Can E., Idkowiak-Baldys, Jolanta, Obeid, Lina M., Clarke, Christopher J., Hannun, Yusuf A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868841/
https://ncbi.nlm.nih.gov/pubmed/24121461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-230557
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