Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

Ceramide synthases (CerS1–CerS6), which catalyze the N-acylation of the (dihydro)sphingosine backbone to produce (dihydro)ceramide in both the de novo and the salvage or recycling pathway of ceramide generation, have been implicated in the control of programmed cell death. However, the regulation of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hernández-Corbacho, María José, Canals, Daniel, Adada, Mohamad M., Liu, Mengling, Senkal, Can E., Yi, Jae Kyo, Mao, Cungui, Luberto, Chiara, Hannun, Yusuf A., Obeid, Lina M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646185/
https://ncbi.nlm.nih.gov/pubmed/26318452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658658
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