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Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages

Acid sphingomyelinase (ASMase) has been proposed to mediate lipopolysaccharide (LPS) signaling in various cell types. This study shows that ASMase is a negative regulator of LPS-induced tumor necrosis factor α (TNFα) secretion in macrophages. ASMase-deficient (asm(−/−)) mice and isolated peritoneal...

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Detalhes bibliográficos
Main Authors: Rozenova, Krasimira A., Deevska, Gergana M., Karakashian, Alexander A., Nikolova-Karakashian, Mariana N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898350/
https://ncbi.nlm.nih.gov/pubmed/20236926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080671
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