Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

Tumor necrosis factor α (TNFα) is a well known cytokine involved in systemic and acute inflammation. In this study, we demonstrate that ceramide 1-phosphate (C1P) produced by ceramide kinase (CERK) is a negative regulator of LPS-induced TNFα secretion. Specifically, bone marrow-derived macrophages i...

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Detalhes bibliográficos
Main Authors: Lamour, Nadia F., Wijesinghe, Dayanjan S., Mietla, Jennifer A., Ward, Katherine E., Stahelin, Robert V., Chalfant, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234830/
https://ncbi.nlm.nih.gov/pubmed/22009748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310169
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