Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α–converting enzyme

Theta-defensins (θ-defensins) are macrocyclic peptides expressed exclusively in granulocytes and selected epithelia of Old World monkeys. They contribute to anti-pathogen host defense responses by directly killing a diverse range of microbes. Of note, θ-defensins also modulate microbe-induced inflam...

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Vydáno v:J Biol Chem
Hlavní autoři: Schaal, Justin B., Maretzky, Thorsten, Tran, Dat Q., Tran, Patti A., Tongaonkar, Prasad, Blobel, Carl P., Ouellette, André J., Selsted, Michael E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827436/
https://ncbi.nlm.nih.gov/pubmed/29317500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000793
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