Ceramide 1-Phosphate Is Required for the Translocation of Group IVA Cytosolic Phospholipase A(2) and Prostaglandin Synthesis

Little is known about the regulation of eicosanoid synthesis proximal to the activation of cytosolic phospholipase A(2)α (cPLA(2)α), the initial rate-limiting step. The current view is that cPLA(2)α associates with intracellular/phosphatidylcholine-rich membranes strictly via hydrophobic interaction...

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Detalhes bibliográficos
Main Authors: Lamour, Nadia F., Subramanian, Preeti, Wijesinghe, Dayanjan S., Stahelin, Robert V., Bonventre, Joseph V., Chalfant, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785377/
https://ncbi.nlm.nih.gov/pubmed/19632995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.001677
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