JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase A(2)

The biogenesis of lipid droplets (LD) induced by serum depends on group IVA phospholipase A(2) (cPLA(2)α). This work dissects the pathway leading to cPLA(2)α activation and LD biogenesis. Both processes were Ca(2+)-independent, as they took place after pharmacological blockade of Ca(2+) transients e...

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Библиографические подробности
Главные авторы: Gubern, Albert, Barceló-Torns, Miquel, Barneda, David, López, José M., Masgrau, Roser, Picatoste, Fernando, Chalfant, Charles E., Balsinde, Jesús, Balboa, María A., Claro, Enrique
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781651/
https://ncbi.nlm.nih.gov/pubmed/19778898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061515
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