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JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase A(2)

The biogenesis of lipid droplets (LD) induced by serum depends on group IVA phospholipase A(2) (cPLA(2)α). This work dissects the pathway leading to cPLA(2)α activation and LD biogenesis. Both processes were Ca(2+)-independent, as they took place after pharmacological blockade of Ca(2+) transients e...

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Detalhes bibliográficos
Main Authors: Gubern, Albert, Barceló-Torns, Miquel, Barneda, David, López, José M., Masgrau, Roser, Picatoste, Fernando, Chalfant, Charles E., Balsinde, Jesús, Balboa, María A., Claro, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781651/
https://ncbi.nlm.nih.gov/pubmed/19778898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061515
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