JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase A(2)

The biogenesis of lipid droplets (LD) induced by serum depends on group IVA phospholipase A(2) (cPLA(2)α). This work dissects the pathway leading to cPLA(2)α activation and LD biogenesis. Both processes were Ca(2+)-independent, as they took place after pharmacological blockade of Ca(2+) transients e...

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Bibliographic Details
Main Authors: Gubern, Albert, Barceló-Torns, Miquel, Barneda, David, López, José M., Masgrau, Roser, Picatoste, Fernando, Chalfant, Charles E., Balsinde, Jesús, Balboa, María A., Claro, Enrique
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781651/
https://ncbi.nlm.nih.gov/pubmed/19778898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061515
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