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Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A(2)-dependent synthesis of lipid droplets in human monocytes

Exposure of human peripheral blood monocytes to free arachidonic acid (AA) results in the rapid induction of lipid droplet (LD) formation by these cells. This effect appears specific for AA in that it is not mimicked by other fatty acids, whether saturated or unsaturated. LDs are formed by two diffe...

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Detalhes bibliográficos
Main Authors: Guijas, Carlos, Pérez-Chacón, Gema, Astudillo, Alma M., Rubio, Julio M., Gil-de-Gómez, Luis, Balboa, María A., Balsinde, Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466003/
https://ncbi.nlm.nih.gov/pubmed/22949356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M028423
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