Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

Ceramide synthases (CerS1–CerS6), which catalyze the N-acylation of the (dihydro)sphingosine backbone to produce (dihydro)ceramide in both the de novo and the salvage or recycling pathway of ceramide generation, have been implicated in the control of programmed cell death. However, the regulation of...

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Vydáno v:J Biol Chem
Hlavní autoři: Hernández-Corbacho, María José, Canals, Daniel, Adada, Mohamad M., Liu, Mengling, Senkal, Can E., Yi, Jae Kyo, Mao, Cungui, Luberto, Chiara, Hannun, Yusuf A., Obeid, Lina M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646185/
https://ncbi.nlm.nih.gov/pubmed/26318452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658658
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