Alteration of Ceramide Synthase 6/C(16)-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca(2+) and ER/Golgi Membrane Network

Mechanisms that regulate endoplasmic reticulum (ER) stress-induced apoptosis in cancer cells remain enigmatic. Recent data suggest that ceramide synthase1–6 (CerS1–6)-generated ceramides, containing different fatty acid chain lengths, might exhibit distinct and opposing functions, such as apoptosis...

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Hlavní autoři: Senkal, Can E., Ponnusamy, Suriyan, Manevich, Yefim, Meyers-Needham, Marisa, Saddoughi, Sahar A., Mukhopadyay, Archana, Dent, Paul, Bielawski, Jacek, Ogretmen, Besim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234959/
https://ncbi.nlm.nih.gov/pubmed/22013072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.287383
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