Antiapoptotic roles of ceramide-synthase-6-generated C(16)-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

Emerging results suggest that ceramides with different fatty acid chain lengths might play distinct functions in the regulation of tumor growth and therapy. Here we report that de novo-generated C(18)- and C(16)-ceramides by ceramide synthases 1 and 6 (CerS1 and CerS6) play opposing proapoptotic and...

Full description

Saved in:
Bibliographic Details
Main Authors: Senkal, Can E., Ponnusamy, Suriyan, Bielawski, Jacek, Hannun, Yusuf A., Ogretmen, Besim
Format: Artigo
Language:Inglês
Published: The Federation of American Societies for Experimental Biology 2010
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797032/
https://ncbi.nlm.nih.gov/pubmed/19723703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-135087
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items