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Antiapoptotic roles of ceramide-synthase-6-generated C(16)-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
Emerging results suggest that ceramides with different fatty acid chain lengths might play distinct functions in the regulation of tumor growth and therapy. Here we report that de novo-generated C(18)- and C(16)-ceramides by ceramide synthases 1 and 6 (CerS1 and CerS6) play opposing proapoptotic and...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Federation of American Societies for Experimental Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797032/ https://ncbi.nlm.nih.gov/pubmed/19723703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-135087 |
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