Antiapoptotic roles of ceramide-synthase-6-generated C(16)-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

Emerging results suggest that ceramides with different fatty acid chain lengths might play distinct functions in the regulation of tumor growth and therapy. Here we report that de novo-generated C(18)- and C(16)-ceramides by ceramide synthases 1 and 6 (CerS1 and CerS6) play opposing proapoptotic and...

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Detalhes bibliográficos
Main Authors: Senkal, Can E., Ponnusamy, Suriyan, Bielawski, Jacek, Hannun, Yusuf A., Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797032/
https://ncbi.nlm.nih.gov/pubmed/19723703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-135087
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