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Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Mechanisms by which autophagy promotes cell survival or death are unclear. We provide evidence that C(18)-pyridinium ceramide (C(18)-Pyr-Cer) treatment, or endogenous C(18)-ceramide generation by ceramide synthase 1 (CerS1) expression mediates autophagic cell death, independent of apoptosis in human...
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| Main Authors: | , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3689583/ https://ncbi.nlm.nih.gov/pubmed/22922758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1059 |
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