Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

Mechanisms by which autophagy promotes cell survival or death are unclear. We provide evidence that C(18)-pyridinium ceramide (C(18)-Pyr-Cer) treatment, or endogenous C(18)-ceramide generation by ceramide synthase 1 (CerS1) expression mediates autophagic cell death, independent of apoptosis in human...

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Autori principali: Sentelle, R. David, Senkal, Can E., Jiang, Wenhui, Ponnusamy, Suriyan, Gencer, Salih, Selvam, Shanmugam Panneer, Ramshesh, Venkat K., Peterson, Yuri K., Lemasters, John J., Szulc, Zdzislaw M., Bielawski, Jacek, Ogretmen, Besim
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689583/
https://ncbi.nlm.nih.gov/pubmed/22922758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1059
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