The Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structure-Activity Relationship Modeling, Virtual Screening, and Experimen...

Por Peterson, Yuri K., Wang, Xiang S., Casey, Patrick J., Tropsha, Alexander
Publicado em 2009

Effects of Pharmacologic Inhibition of Protein Geranylgeranyltransferase Type I on Aqueous Humor Outflow through the Trabecular Meshwork

Por Vasantha Rao, P., Peterson, Yuri K., Inoue, Toshihiro, Casey, Patrick J.
Publicado em 2008

Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases

Por Gao, Peng, Peterson, Yuri K., Smith, Ryan A., Smith, Charles D.
Publicado em 2012

Suppression of GNAI2 message in ovarian cancer

Por Raymond, John R, Appleton, Kathryn M, Pierce, Jennifer Y, Peterson, Yuri K
Publicado em 2014

A High-Content, Live-Cell, and Real-Time Approach to the Quantitation of Ligand-Induced β-Arrestin2 and Class A/Class B GPCR Mobilization

Por Leonard, Anthony P., Appleton, Kathryn M., Luttrell, Louis M., Peterson, Yuri K.
Publicado em 2013

High-Throughput Screening for Novel Inhibitors of Neisseria gonorrhoeae Penicillin-Binding Protein 2

Por Fedarovich, Alena, Djordjevic, Kevin A., Swanson, Shauna M., Peterson, Yuri K., Nicholas, Robert A., Davies, Christopher
Publicado em 2012

Development of inhibitors of heterotrimeric Gα(i) subunits

Por Appleton, Kathryn M., Bigham, Kevin J., Lindsey, Christopher C., Hazard, Starr, Lirjoni, Jonel, Parnham, Stuart, Hennig, Mirko, Peterson, Yuri K.
Publicado em 2014

The β(2)-Adrenoceptor Agonist Formoterol Stimulates Mitochondrial Biogenesis

Por Wills, Lauren P., Trager, Richard E., Beeson, Gyda C., Lindsey, Christopher C., Peterson, Yuri K., Beeson, Craig C., Schnellmann, Rick G.
Publicado em 2012

High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury

Por Wills, Lauren P., Beeson, Gyda C., Trager, Richard E., Lindsey, Christopher C., Beeson, Craig C., Peterson, Yuri K., Schnellmann, Rick G.
Publicado em 2013

β(2)-adrenoceptor agonists in the regulation of mitochondrial biogenesis

Por Peterson, Yuri K., Cameron, Robert B., Wills, Lauren P., Trager, Richard E., Lindsey, Chris C., Beeson, Craig C., Schnellmann, Rick G.
Publicado em 2013

Quantitative Analysis of Mitochondrial Morphology and Membrane Potential in Living Cells Using High-Content Imaging, Machine Learning, and Morphological Binning

Por Leonard, Anthony P., Cameron, Robert B., Speiser, Jaime L., Wolf, Bethany J., Peterson, Yuri K., Schnellmann, Rick G., Beeson, Craig C., Rohrer, Baerbel
Publicado no Biochim Biophys Acta (2014)

The conformational signature of arrestin3 predicts its trafficking and signaling functions

Por Lee, Mi-Hye, Appleton, Kathryn M., Strungs, Erik G., Kwon, Joshua Y., Morinelli, Thomas A., Peterson, Yuri K., Laporte, Stephane A., Luttrell, Louis M.
Publicado no Nature (2016)

The Arrestin-selective Angiotensin AT(1) Receptor Agonist [Sar(1),Ile(4),Ile(8)]-AngII Negatively Regulates Bradykinin B(2) Receptor Signaling via AT(1)-B(2) Receptor Heterodimers

Por Wilson, Parker C., Lee, Mi-Hye, Appleton, Kathryn M., El-Shewy, Hesham M., Morinelli, Thomas A., Peterson, Yuri K., Luttrell, Louis M., Jaffa, Ayad A.
Publicado em 2013

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation()

Por Selvam, Shanmugam P., De Palma, Ryan M., Oaks, Joshua J., Oleinik, Natalia, Peterson, Yuri K., Stahelin, Robert V., Skordalakes, Emmanuel, Ponnusamy, Suriyan, Garrett-Mayer, Elizabeth, Smith, Charles D., Ogretmen, Besim
Publicado no Sci Signal (2015)

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

Por Sentelle, R. David, Senkal, Can E., Jiang, Wenhui, Ponnusamy, Suriyan, Gencer, Salih, Selvam, Shanmugam Panneer, Ramshesh, Venkat K., Peterson, Yuri K., Lemasters, John J., Szulc, Zdzislaw M., Bielawski, Jacek, Ogretmen, Besim
Publicado em 2012

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Por Saddoughi, Sahar A, Gencer, Salih, Peterson, Yuri K, Ward, Katherine E, Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M, Thomas, Raquela J, Selvam, Shanmugam P, Senkal, Can E, Garrett-Mayer, Elizabeth, De Palma, Ryan M, Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A, Stahelin, Robert V, Perrotti, Danilo, Ogretmen, Besim
Publicado em 2013