Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation()

During DNA replication, the enzyme telomerase maintains the ends of chromosomes, called telomeres. Shortened telomeres trigger cell senescence, and cancer cells often have increased telomerase activity to promote their ability to proliferate indefinitely. The catalytic subunit, human telomerase reve...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Signal
Egile Nagusiak: Selvam, Shanmugam P., De Palma, Ryan M., Oaks, Joshua J., Oleinik, Natalia, Peterson, Yuri K., Stahelin, Robert V., Skordalakes, Emmanuel, Ponnusamy, Suriyan, Garrett-Mayer, Elizabeth, Smith, Charles D., Ogretmen, Besim
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492107/
https://ncbi.nlm.nih.gov/pubmed/26082434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa4998
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