Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation()

During DNA replication, the enzyme telomerase maintains the ends of chromosomes, called telomeres. Shortened telomeres trigger cell senescence, and cancer cells often have increased telomerase activity to promote their ability to proliferate indefinitely. The catalytic subunit, human telomerase reve...

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Pubblicato in:Sci Signal
Autori principali: Selvam, Shanmugam P., De Palma, Ryan M., Oaks, Joshua J., Oleinik, Natalia, Peterson, Yuri K., Stahelin, Robert V., Skordalakes, Emmanuel, Ponnusamy, Suriyan, Garrett-Mayer, Elizabeth, Smith, Charles D., Ogretmen, Besim
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492107/
https://ncbi.nlm.nih.gov/pubmed/26082434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa4998
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