High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury

Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores de...

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Bibliographic Details
Main Authors: Wills, Lauren P., Beeson, Gyda C., Trager, Richard E., Lindsey, Christopher C., Beeson, Craig C., Peterson, Yuri K., Schnellmann, Rick G.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987703/
https://ncbi.nlm.nih.gov/pubmed/23811330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.06.014
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