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The conformational signature of arrestin3 predicts its trafficking and signaling functions
Arrestins are cytosolic proteins that regulate G protein-coupled receptor (GPCR) desensitization, internalization, trafficking, and signaling(1,2). Arrestin recruitment uncouples GPCRs from heterotrimeric G proteins, and targets them for internalization via clathrin-coated pits(3,4). Arrestins also...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4973468/ https://ncbi.nlm.nih.gov/pubmed/27007854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17154 |
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