The conformational signature of arrestin3 predicts its trafficking and signaling functions

Arrestins are cytosolic proteins that regulate G protein-coupled receptor (GPCR) desensitization, internalization, trafficking, and signaling(1,2). Arrestin recruitment uncouples GPCRs from heterotrimeric G proteins, and targets them for internalization via clathrin-coated pits(3,4). Arrestins also...

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Publicado en:Nature
Main Authors: Lee, Mi-Hye, Appleton, Kathryn M., Strungs, Erik G., Kwon, Joshua Y., Morinelli, Thomas A., Peterson, Yuri K., Laporte, Stephane A., Luttrell, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973468/
https://ncbi.nlm.nih.gov/pubmed/27007854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17154
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