Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Mechanisms that alter protein phosphatase 2A (PP2A)-dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor ceramide binds I2PP2A/SET selectively in the nucleus and including its K209 and Y122 residues as determined by molecular modelling...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Saddoughi, Sahar A, Gencer, Salih, Peterson, Yuri K, Ward, Katherine E, Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M, Thomas, Raquela J, Selvam, Shanmugam P, Senkal, Can E, Garrett-Mayer, Elizabeth, De Palma, Ryan M, Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A, Stahelin, Robert V, Perrotti, Danilo, Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569657/
https://ncbi.nlm.nih.gov/pubmed/23180565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201283
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados