A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

Enhanced ceramide glycosylation catalyzed by glucosylceramide synthase (GCS) limits therapeutic efficiencies of antineoplastic agents including doxorubicin in drug-resistant cancer cells. Aimed to determine the role of GCS in tumor response to chemotherapy, a new mixed-backbone oligonucleotide (MBO-...

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Detalhes bibliográficos
Main Authors: Patwardhan, Gauri A., Zhang, Qian-Jin, Yin, Dongmei, Gupta, Vineet, Bao, Jianxiong, Senkal, Can E., Ogretmen, Besim, Cabot, Myles C., Shah, Girish V., Sylvester, Paul W., Jazwinski, S. Michal, Liu, Yong-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735002/
https://ncbi.nlm.nih.gov/pubmed/19742320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006938
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