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Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma
Drug resistance causes treatment failure in approximately 50% of breast cancer patients with chemotherapy. Overexpression of glucosylceramide synthase (GCS) confers drug resistance in cancer cells, and suppression of GCS sensitizes cancers to chemotherapy in preclinical studies. Thus, GCS becomes a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4037863/ https://ncbi.nlm.nih.gov/pubmed/21617856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1052 |
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