Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma

Drug resistance causes treatment failure in approximately 50% of breast cancer patients with chemotherapy. Overexpression of glucosylceramide synthase (GCS) confers drug resistance in cancer cells, and suppression of GCS sensitizes cancers to chemotherapy in preclinical studies. Thus, GCS becomes a...

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Bibliografiske detaljer
Main Authors: LIU, YONG-YU, PATWARDHAN, GAURI A., XIE, PING, GU, XIN, GIULIANO, ARMANDO E., CABOT, MYLES C.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037863/
https://ncbi.nlm.nih.gov/pubmed/21617856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1052
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