Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase

Glucosylceramide synthase (GCS or GlcT-1), converting ceramide to glucosylceramide, is a key enzyme for the synthesis of glycosphingolipids. Due to its diverse roles in physiology and diseases, GCS may be a disease marker and drug target. Current assays for enzymes including GCS are based on reactio...

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Dettagli Bibliografici
Autori principali: Gupta, Vineet, Patwardhan, Gauri A., Zhang, Qian-Jin, Cabot, Myles C., Jazwinski, S. Michal, Liu, Yong-Yu
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Methods
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842142/
https://ncbi.nlm.nih.gov/pubmed/19826105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.D002949
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