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Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells

Tumor suppressor p53 plays an essential role in protecting cells from malignant transformation by inducing cell cycle arrest and apoptosis. Mutant p53 that is detected in over 50% cases of cancers not only loses its role in suppressing of tumor but also gains oncogenic function. Strategies to conver...

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Bibliografiske detaljer
Main Authors: Liu, Yong-Yu, Patwardhan, Gauri A., Bhinge, Kaustubh, Gupta, Vineet, Gu, Xin, Jazwinski, S. Michal
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059346/
https://ncbi.nlm.nih.gov/pubmed/21278235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3107
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