Energetics of Heterotropic Cooperativity between α-Naphthoflavone and Testosterone Binding to CYP3A4

by Roberts, Arthur G., Atkins, William M.
Published 2007

Mechanisms and the clinical relevance of complex drug–drug interactions

by Roberts, Arthur G, Gibbs, Morgan E
Published in Clin Pharmacol (2018)

Cardiovascular Ion Channel Inhibitor Drug-Drug Interactions with P-glycoprotein

by Ledwitch, Kaitlyn V., Roberts, Arthur G.
Published in AAPS J (2016)

Insights into the Molecular Mechanism of Triptan Transport by P-glycoprotein

by Wilt, Laura A., Nguyen, Diana, Roberts, Arthur G.
Published in J Pharm Sci (2017)

Structural Features of Cytochromes P450 and Ligands that Affect Drug Metabolism as Revealed by X-ray Crystallography and NMR

by Gay, Sean C., Roberts, Arthur G., Halpert, James R.
Published 2010

Unravelling the complex drug–drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein

by Ledwitch, Kaitlyn V., Barnes, Robert W., Roberts, Arthur G.
Published in Biosci Rep (2016)

Cooperativity between Verapamil and ATP Bound to the Efflux Transporter P-glycoprotein

by Ledwitch, Kaitlyn V., Gibbs, Morgan E., Barnes, Robert W., Roberts, Arthur G.
Published in Biochem Pharmacol (2016)

A conformationally-gated model of methadone and loperamide transport by P-glycoprotein

by Gibbs, Morgan E., Wilt, Laura A., Ledwitch, Kaitlyn V., Roberts, Arthur G.
Published in J Pharm Sci (2018)

The Stereochemical Course of 4-Hydroxy-2-nonenal Metabolism by Glutathione S-Transferases

by Balogh, Larissa M., Roberts, Arthur G., Shireman, Laura M., Greene, Robert J., Atkins, William M.
Published 2008

NMR-Derived Models of Amidopyrine and its Metabolites Complexed to Rabbit Cytochrome P450 2B4 Reveal a Structural Mechanism of Sequential N-Dealkylation()

by Roberts, Arthur G., Sjögren, Sara E. A., Fomina, Nadezda, Vu, Kathy T., Almutairi, Adah, Halpert, James R.
Published 2011

The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4()

by Roberts, Arthur G., Yang, Jing, Halpert, James R., Nelson, Sidney D., Thummel, Kenneth T., Atkins, William M.
Published 2011

Cysteine 98 in CYP3A4 Contributes to Conformational Integrity Required for P450 Interaction with CYP Reductase

by Wen, Bo, Lampe, Jed N., Roberts, Arthur G., Atkins, William M., Rodrigues, A. David, Nelson, Sidney D.
Published 2006

Intramolecular Heme Ligation of the CYP2C9 R108H Mutant Demonstrates Pronounced Conformational Flexibility of the B-C Loop Region: Implications for Substrate Binding

by Roberts, Arthur G., Cheesman, Matthew J., Primak, Andrew, Bowman, Michael K., Atkins, William M., Rettie, Allan E.
Published 2010

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel

by Gay, Sean C., Roberts, Arthur G., Maekawa, Keiko, Talakad, Jyothi C., Hong, Wen-Xu, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Published 2010

Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes

by Shimshoni, Jakob A., Roberts, Arthur G., Scian, Michele, Topletz, Ariel R., Blankert, Sean A., Halpert, James R., Nelson, Wendel L., Isoherranen, Nina
Published 2012

Cross-linking Mass Spectrometry and Mutagenesis Confirm the Functional Importance of Surface Interactions between CYP3A4 and Holo/Apo Cytochrome b(5)

by Zhao, Chunsheng, Gao, Qiuxia, Roberts, Arthur G., Shaffer, Scott A., Doneanu, Catalin E., Xue, Song, Goodlett, David R., Nelson, Sidney D., Atkins, William M.
Published 2012

Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography

by Wilderman, P. Ross, Shah, Manish B., Liu, Tong, Li, Sheng, Hsu, Simon, Roberts, Arthur G., Goodlett, David R., Zhang, Qinghai, Woods, Virgil L., Stout, C. David, Halpert, James R.
Published 2010

Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity

by Gay, Sean C., Zhang, Haoming, Wilderman, P. Ross, Roberts, Arthur G., Liu, Tong, Li, Sheng, Lin, Hsia-lien, Zhang, Qinghai, Woods, Virgil L., Stout, C. David, Hollenberg, Paul F., Halpert, James R.
Published 2011

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-Å Resolution

by Gay, Sean C., Shah, Manish B., Talakad, Jyothi C., Maekawa, Keiko, Roberts, Arthur G., Wilderman, P. Ross, Sun, Ling, Yang, Jane Y., Huelga, Stephanie C., Hong, Wen-Xu, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Published 2010

Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function

by Zhong, Weilong, Sun, Bo, Ruan, Hao, Yang, Guang, Qian, Baoxin, Cao, Hailong, He, Lingfei, Fan, Yunjing, Roberts, Arthur G., Liu, Xiang, Hu, Xuejiao, Liang, Yuan, Ye, Qing, Yin, Tingting, Wang, Bangmao, Yang, Cheng, Sun, Tao, Zhou, Honggang
Published in iScience (2020)