Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes

All-trans-retinoic acid (atRA), the major active metabolite of vitamin A, plays a role in many biological processes, including maintenance of epithelia, immunity, and fertility and regulation of apoptosis and cell differentiation. atRA is metabolized mainly by CYP26A1, but other P450 enzymes such as...

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Hlavní autoři: Shimshoni, Jakob A., Roberts, Arthur G., Scian, Michele, Topletz, Ariel R., Blankert, Sean A., Halpert, James R., Nelson, Wendel L., Isoherranen, Nina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516766/
https://ncbi.nlm.nih.gov/pubmed/23071109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404475
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