Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance

per Huang, Weize, Isoherranen, Nina
Publicat a CPT Pharmacometrics Syst Pharmacol (2018)

Biochemical and Physiological Importance of the CYP26 Retinoic Acid Hydroxylases

per Isoherranen, Nina, Zhong, Guo
Publicat a Pharmacol Ther (2019)

Sampling Site Has a Critical Impact on Physiologically Based Pharmacokinetic Modeling

per Huang, Weize, Isoherranen, Nina
Publicat a J Pharmacol Exp Ther (2020)

Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption

per Huang, Weize, Isoherranen, Nina
Publicat a CPT Pharmacometrics Syst Pharmacol (2020)

Human fetal liver metabolism of oxycodone is mediated by CYP3A7

per Shum, Sara, Isoherranen, Nina
Publicat a AAPS J (2021)

The role of CYP26 enzymes in retinoic acid clearance

per Thatcher, Jayne E., Isoherranen, Nina
Publicat 2009

Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole

per Lutz, Justin D., Isoherranen, Nina
Publicat 2012

Drug Metabolism and Transport During Pregnancy: How Does Drug Disposition Change during Pregnancy and What Are the Mechanisms that Cause Such Changes?

per Isoherranen, Nina, Thummel, Kenneth E.
Publicat 2013

Pharmacokinetics of Gentamicin C(1), C(1a), and C(2) in Beagles after a Single Intravenous Dose

per Isoherranen, Nina, Lavy, Eran, Soback, Stefan
Publicat 2000

The role of metabolites in predicting drug-drug interactions: Focus on irreversible P450 inhibition

per VandenBrink, Brooke M., Isoherranen, Nina
Publicat 2010

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid

per Thatcher, Jayne E., Zelter, Alex, Isoherranen, Nina
Publicat 2010

Rationalization and prediction of in vivo metabolite exposures: The role of metabolite kinetics, clearance predictions and in vitro parameters

per Lutz, Justin D., Fujioka, Yasushi, Isoherranen, Nina
Publicat 2010

Pregnancy Decreases Rat CYP1A2 Activity and Expression

per Walker, Alysa A., Dickmann, Leslie, Isoherranen, Nina
Publicat 2011

Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions

per Fujioka, Yasushi, Kunze, Kent L., Isoherranen, Nina
Publicat 2012

Sample matrix has a major impact on accuracy of peptide quantification: Assessment of calibrator and internal standard selection and method validation

per Arnold, Samuel L., Stevison, Faith, Isoherranen, Nina
Publicat a Anal Chem (2015)

Scaling in vitro activity of CYP3A7 suggests human fetal livers do not clear retinoic acid entering from maternal circulation

per Topletz, Ariel R., Zhong, Guo, Isoherranen, Nina
Publicat a Sci Rep (2019)

Emerging Role of Organ‐on‐a‐Chip Technologies in Quantitative Clinical Pharmacology Evaluation

per Isoherranen, Nina, Madabushi, Rajanikanth, Huang, Shiew‐Mei
Publicat a Clin Transl Sci (2019)

Mechanistic PBPK Modeling of Urine pH Effect on Renal and Systemic Disposition of Methamphetamine and Amphetamine

per Huang, Weize, Czuba, Lindsay C., Isoherranen, Nina
Publicat a J Pharmacol Exp Ther (2020)

A Comparison of the Roles of Peroxisome Proliferator-Activated Receptor and Retinoic Acid Receptor on CYP26 Regulation

per Tay, Suzanne, Dickmann, Leslie, Dixit, Vaishali, Isoherranen, Nina
Publicat 2010

Therapeutic Potential of the Inhibition of the Retinoic Acid Hydroxylases CYP26A1 and CYP26B1 by Xenobiotics

per Nelson, Cara H, Buttrick, Brian R, Isoherranen, Nina
Publicat a Curr Top Med Chem (2013)