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Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions
Drug-drug interactions (DDIs) that occur via mechanism-based inactivation of cytochrome P450 are of serious concern. Although several predictive models have been published, early risk assessment of MBIs is still challenging. For reversible inhibitors, the DDI risk categorization using [I]/K(i) ([I],...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422541/ https://ncbi.nlm.nih.gov/pubmed/22685217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.046649 |
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