Loading...

Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems

Recent guidance on drug-drug interaction (DDI) testing recommends evaluation of circulating metabolites. However, there is little consensus on how to quantitatively predict and/or assess the risk of in vivo DDIs by multiple time-dependent inhibitors (TDIs) including metabolites from in vitro data. F...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Lutz, Justin D., VandenBrink, Brooke M., Babu, Katipudi N., Nelson, Wendel L., Kunze, Kent L., Isoherranen, Nina
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834134/
https://ncbi.nlm.nih.gov/pubmed/23785064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052639
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!