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Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 in vivo
Itraconazole (ITZ) is metabolized in vitro to three inhibitory metabolites: hydroxy-ITZ (OH-ITZ), keto-ITZ, and N-desalkyl-ITZ (ND-ITZ). The goal of this study was to determine the contribution of these metabolites to drug-drug interactions caused by ITZ. Six healthy volunteers received 100 mg ITZ o...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488349/ https://ncbi.nlm.nih.gov/pubmed/17495874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.clpt.6100230 |
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