Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, (S)-Fluoxetine, and N-Desmethyldiltiazem

Three secondary amines desipramine (DES), (S)-fluoxetine [(S)-FLX], and N-desmethyldiltiazem (MA) undergo N-hydroxylation to the corresponding secondary hydroxylamines [N-hydroxydesipramine, (S)-N-hydroxyfluoxetine, and N-hydroxy-N-desmethyldiltiazem] by cytochromes P450 2C11, 2C19, and 3A4, respect...

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Detalhes bibliográficos
Main Authors: Hanson, Kelsey L., VandenBrink, Brooke M., Babu, Kantipudi N., Allen, Kyle E., Nelson, Wendel L., Kunze, Kent L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879960/
https://ncbi.nlm.nih.gov/pubmed/20200233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.032391
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