Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions

por Fujioka, Yasushi, Kunze, Kent L., Isoherranen, Nina
Publicado 2012

Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: O-18 Protein Labeling Studies

por Baer, Brian R., Kunze, Kent L., Rettie, Allan E.
Publicado 2007

Allosteric Activation of Cytochrome P450 3A4 by α-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis()

por Woods, Caleb M., Fernandez, Cristina, Kunze, Kent L., Atkins, William M.
Publicado 2011

Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy

por Zhang, Nan, Seguin, Ryan P., Kunze, Kent L., Zhang, Yan-Yan, Jeong, Hyunyoung
Publicado 2013

Surface Plasmon Resonance Analysis of Antifungal Azoles Binding to CYP3A4 with Kinetic Resolution of Multiple Binding Orientations

por Pearson, Josh T., Hill, John J., Swank, Jennifer, Isoherranen, Nina, Kunze, Kent L., Atkins, William M.
Publicado 2006

Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone and their combination as endogenous probes for inhibition of CYP3A4 in vivo

por Peng, Chi-Chi, Templeton, Ian, Thummel, Kenneth E, Davis, Connie, Kunze, Kent L, Isoherranen, Nina
Publicado 2011

Fluoxetine and norfluoxetine mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19 and CYP3A4

por Sager, Jennifer E, Lutz, Justin D, Foti, Robert S, Davis, Connie, Kunze, Kent L, Isoherranen, Nina
Publicado 2014

Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 in vivo

por Templeton, Ian, Thummel, Kenneth E, Kharasch, Evan D, Kunze, Kent L, Hoffer, Christine, Nelson, Wendel L, Isoherranen, Nina
Publicado 2007

Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems

por Lutz, Justin D., VandenBrink, Brooke M., Babu, Katipudi N., Nelson, Wendel L., Kunze, Kent L., Isoherranen, Nina
Publicado 2013

Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, (S...

por Hanson, Kelsey L., VandenBrink, Brooke M., Babu, Kantipudi N., Allen, Kyle E., Nelson, Wendel L., Kunze, Kent L.
Publicado 2010

Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals

por Peng, Chi-Chi, Shi, Wei, Lutz, Justin D., Kunze, Kent L., Liu, Jun O., Nelson, Wendel L., Isoherranen, Nina
Publicado 2012