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Allosteric Activation of Cytochrome P450 3A4 by α-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis()
Cytochrome P450 3A4 is the dominant xenobiotic metabolizing CYP. Despite great interest in CYP enzymology, two in vitro aspects of CYP3A4 catalysis are still not well understood; namely, sequential metabolism and allosteric activation. We have therefore investigated such a system where both phenomen...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226823/ https://ncbi.nlm.nih.gov/pubmed/22004098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2013454 |
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