Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole

Por Lutz, Justin D., Isoherranen, Nina
Publicado em 2012

Rationalization and prediction of in vivo metabolite exposures: The role of metabolite kinetics, clearance predictions and in vitro parameters

Por Lutz, Justin D., Fujioka, Yasushi, Isoherranen, Nina
Publicado em 2010

Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions

Por Shirasaka, Yoshiyuki, Sager, Jennifer E., Lutz, Justin D., Davis, Connie, Isoherranen, Nina
Publicado em 2013

Fluoxetine and norfluoxetine mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19 and CYP3A4

Por Sager, Jennifer E, Lutz, Justin D, Foti, Robert S, Davis, Connie, Kunze, Kent L, Isoherranen, Nina
Publicado em 2014

Importance of multi-P450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude and prediction from in vitro data

Por Isoherranen, Nina, Lutz, Justin D, Chung, Sophie P, Hachad, Houda, Levy, Rene H, Ragueneau-Majlessi, Isabelle
Publicado em 2012

Direct protein-protein interactions and substrate channelling between cellular retinoic acid binding proteins and CYP26B1

Por Nelson, Cara H, Peng, Chi-Chi, Lutz, Justin D., Yeung, Catherine K., Zelter, Alex, Isoherranen, Nina
Publicado no FEBS Lett (2016)

Comparison of the Function and Expression of CYP26A1 and CYP26B1, the two Retinoic Acid Hydroxylases

Por Topletz, Ariel R., Thatcher, Jayne E., Zelter, Alex, Lutz, Justin D., Tay, Suzanne, Nelson, Wendel L., Isoherranen, Nina
Publicado em 2011

Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems

Por Lutz, Justin D., VandenBrink, Brooke M., Babu, Katipudi N., Nelson, Wendel L., Kunze, Kent L., Isoherranen, Nina
Publicado em 2013

Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals

Por Peng, Chi-Chi, Shi, Wei, Lutz, Justin D., Kunze, Kent L., Liu, Jun O., Nelson, Wendel L., Isoherranen, Nina
Publicado em 2012

Expression and Functional Characterization of Cytochrome P450 26A1, a Retinoic Acid Hydroxylase

Por Lutz, Justin D, Dixit, Vaishali, Yeung, Catherine K, Dickmann, Leslie J, Zelter, Alex, Thatcher, Jayne E, Nelson, Wendel L, Isoherranen, Nina
Publicado em 2008

Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator

Por Williams, Daphne, Tao, Xiaolu, Zhu, Lili, Stonier, Michele, Lutz, Justin D., Masson, Eric, Zhang, Sean, Ganguly, Bishu, Tzogas, Zoe, Lubin, Susan, Murthy, Bindu
Publicado no Br J Clin Pharmacol (2016)

Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics

Por Tay-Sontheimer, Jessica, Shireman, Laura M, Beyer, Richard P, Senn, Taurence, Witten, Daniela, Pearce, Robin E, Gaedigk, Andrea, Fomban, Cletus L Gana, Lutz, Justin D, Isoherranen, Nina, Thummel, Kenneth E, Fiehn, Oliver, Leeder, J Steven, Lin, Yvonne S
Publicado no Pharmacogenomics (2014)

A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

Por Ojo, Kayode K., Eastman, Richard T., Vidadala, RamaSubbaRao, Zhang, Zhongsheng, Rivas, Kasey L., Choi, Ryan, Lutz, Justin D., Reid, Molly C., Fox, Anna M. W., Hulverson, Matthew A., Kennedy, Mark, Isoherranen, Nina, Kim, Laura M., Comess, Kenneth M., Kempf, Dale J., Verlinde, Christophe L. M. J., Su, Xin-zhuan, Kappe, Stefan H. I., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C.
Publicado em 2014