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Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions

The aim of this study was to evaluate the contribution of metabolites to drug-drug interactions (DDI) using the inhibition of CYP2C19 and CYP3A4 by omeprazole and its metabolites as a model. Of the metabolites identified in vivo, 5-hydroxyomeprazole, 5′-O-desmethylomeprazole, omeprazole sulfone, and...

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Bibliografiske detaljer
Main Authors: Shirasaka, Yoshiyuki, Sager, Jennifer E., Lutz, Justin D., Davis, Connie, Isoherranen, Nina
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684819/
https://ncbi.nlm.nih.gov/pubmed/23620487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.051722
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