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Pregnancy Decreases Rat CYP1A2 Activity and Expression
Pregnancy results in increased CYP3A- and CYP2D6-mediated clearance but decreases the clearance of CYP1A2 probe drugs. The aim of this study was to determine whether the decreased CYP1A2 activity during human pregnancy could be explained by decreased expression of CYP1A2 protein and mRNA using the r...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014270/ https://ncbi.nlm.nih.gov/pubmed/20921303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.035766 |
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