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Changes in Maternal liver Cyp2c and Cyp2d Expression and Activity During Rat Pregnancy

During human pregnancy, CYP2C9, CYP2C19, and CYP2D6 activities are altered. The aim of the current study was to determine if this phenomenon can be replicated in the rat, and to evaluate the mechanisms that contribute to the changes in Cyp2c and Cyp2d activity during pregnancy. The intrinsic clearan...

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Detalhes bibliográficos
Main Authors: Dickmann, Leslie J., Tay, Suzanne, Senn, Tauri D., Zhang, Huixia, Visone, Anthony, Unadkat, Jashvant D., Hebert, Mary F., Isoherranen, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683271/
https://ncbi.nlm.nih.gov/pubmed/18342837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.01.012
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